Dr Tom Mules
Clinical Consultant - Mules Research Group
Dr Tom Mules is a physician specialising in gastroenterology and hepatology, and lecturer at the University of Otago School of Medicine.
He leads the Mules Research Group. Tom's research interests include Helicobacter pylori, inflammatory bowel disease, and the role of intestinal barrier dysfunction in disease.
Tom wrote his PhD thesis on the effect of the type 2 immune response on intestinal barrier function, and whether we can design interventional strategies to strengthen the intestinal barrier and treat gut inflammation.
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Publications
2024
Mules TC, Vacca F, Cait A, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Gasser O, Camberis M, Le Gros G, Inns S (2024). A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome. Int J Mol Sci. 25(22):12015.
Noble SL, Mules TC, Le Gros G, Inns S (2024). The immunoregulatory potential of eosinophil subsets. Immunol Cell Biol. 102(9):775-786.
Noble SL, Vacca F, Hilligan KL, Mules TC, Le Gros G, Inns S (2024). Helminth infection induces a distinct subset of CD101hi lung tissue-infiltrating eosinophils that are differentially regulated by type 2 cytokines. Immunol Cell Biol. 102(8):734-746.
Mules TC, Tang JS, Vacca F, Yumnam B, Schmidt A, Lavender B, Maclean K, Noble SL, Waugh C, van Ginkel R, Camberis M, Le Gros G, Inns S (2024). Modulation of intestinal epithelial permeability by chronic small intestinal helminth infections. Immunol Cell Biol. 102(5):396-406
2023
Mules TC, Inns S, Le Gros G (2023). Helminths' therapeutic potential to treat intestinal barrier dysfunction. Allergy. 78(11):2892-2905
Mules TC, Lavender B, Maclean K, Vacca F, Noble SL, Yumnam B, Te Kawa T, Cait A, Tang J, O'Sullivan D, Gasser O, Stanley J, Le Gros G, Camberis M, Inns S (2023). Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial. Inflamm Bowel Dis. 2023 Jun 15