Mules Research Group

Targeting immune-mediated diseases and gut cancer through microbiome and gut barrier modulation.

The gut contains the bulk of the body’s immune system, and interactions within it have profound, far-reaching effects on overall health. By advancing our understanding of how the microbiome, diet, gut-resident immune cells, and the wider immune system interact, we can develop innovative strategies to improve health and combat disease.

The Mules Research Group is focused on three key core areas: defining the microbiome’s role in gut inflammation and conditions such as inflammatory bowel disease, restoring and strengthening gut-barrier function to treat both local and systemic allergic and inflammatory diseases, and targeting Helicobacter pylori to prevent gastric cancer.

Research areas

• Allergic and Inflammatory disease
• Helminth therapy
• Epithelial barrier dysfunction
• Gastric cancer prevention

Research projects

• Molecular testing to improve Helicobacter pylori eradication

• Developing an mRNA vaccine against H. pylori

• Develop novel therapies to treat intestinal barrier dysfunction (butylated starch)

• Bio-engineered Human Hookworm as a Novel Drug Delivery System