A revolutionary new approach to fighting cancer, CAR T-cell therapy has the potential to transform cancer treatment. We're working to make it accessible and affordable for all New Zealanders in need.
CAR T-cell therapy stands for Chimeric Antigen Receptor T-cell therapy. A one-off treatment, it works by redirecting a patient’s own immune cells (T-cells) in the laboratory, to directly identify and attack cancer cells. These modified T-cells are then returned to the patient where they can attack and destroy cancer cells. CAR T-cells have the potential to act as ‘living drugs’, providing long-term protection against relapse.
CAR T-cell therapy has the potential to target a range of cancers, with research and clinical trials underway worldwide. However, to date, it has been effective for treating certain blood cancers, including certain lymphomas, B-cell leukaemias, and myeloma. In Australia, the USA and parts of Europe, CAR T-cell therapies for these types of cancer are licensed for routine use.
In New Zealand, the Malaghan Institute’s CAR T-cell programme includes the country’s first CAR T-cell trial, with on-shore CAR T-cell manufacture and delivery. Our goals are to conduct cutting-edge trials of new CAR T-cell therapies, and to leverage our nationally-unique manufacturing, regulatory and clinical experience to help introduce CAR T-cell therapies as a standard of care in New Zealand.
ENABLE clinical trial
The Malaghan Institute, in partnership with Wellington Zhaotai Therapies, is developing and trialling a new CAR T-cell therapy in New Zealand for patients with certain types of relapsed and refractory B-cell non-Hodgkin lymphoma, who have exhausted other treatment options.
The treatment we are working on is a ‘third generation’ CAR T-cell therapy, which we hope may be at least as safe and effective, and easier to deliver, than treatments currently available elsewhere. However, because ENABLE is an ongoing early-phase trial, the safety and effectiveness of our CAR T-cell therapy has not yet been firmly established.
Our ENABLE phase I safety trial got underway in late 2019, treating participants across the country to determine the optimal dose of the therapy. In January 2023 we treated our 21st and final patient in this dose escalation cohort. We plan to release results later in 2023.
We have now extended the trial based on the optimal dose to incorporate a series of manufacturing and clinical improvements – including automated manufacture using Cocoon technology. This will provide data critical for the design of a larger phase II trial, where the effectiveness can be assessed more robustly.
The Malaghan Institute is not a provider of health services and does not recruit patients to clinical trials directly. Patients should speak to their haematologist or oncologist about whether this, or other clinical trials, might be an option for them. Referrals to the CAR T-cell ENABLE trial must be made by a relevant specialist to the Clinical Trials Unit at Wellington Hospital via [email protected]. A public summary of the ENABLE trial is available on the ClinicalTrials.gov website.
Freemasons CAR T-cell research programme
In parallel with the ENABLE clinical trial, our CAR T-cell research programme is focusing on improving the safety and effectiveness of current CAR T-cells, and expanding this cutting-edge technology to treat a wider range of cancers, including solid tumours.
In Focus: Mastering the technology behind automated CAR T-cell manufacture
14 September 2023
Malaghan Institute and BioOra deliver automated manufacturing to scale up CAR T-cell cancer therapy in NZ
16 August 2023
RNZ: New Zealand developed cancer treatment one step closer to market
17 May 2023
Malaghan PhD student receives Māori Cancer Researcher Award
28 April 2023
International deal for Kiwi cancer therapy biotech
26 April 2023
RNZ: Poet Michele Leggott - waiting for a miracle
8 April 2023