BSc, MSc(Hons), PhD(Auckland)
Mike Berridge completed a doctoral degree in cell biology at the University of Auckland in 1971 exploring the mechanism of action of plant growth hormones. Following postdoctoral research in developmental molecular biology at Purdue University, USA, and experience as a staff scientist at National Institute for Medical Research, Mill Hill, UK, he returned to Wellington in 1976 as the second Malaghan Research Fellow where he established the Cancer Cell & Molecular Biology Research Group and was a founding scientist of the Wellington Cancer & Medical Research Institute, later renamed the Malaghan Institute of Medical Research in recognition of major personal support by Len and Anne Malaghan.
Mike Berridge received a James Cook Fellowship in the health sciences in 2003 and was awarded the Health Research Council Liley Medal for outstanding research on cellular metabolism in 2016. In the same year he was a semi-finalist in the KiwiBank New Zealander of the Year Awards.
Prof Berridge’s current research interests include cancer cell energy metabolism and mitochondrial gene transfer between cells in human disease. As a science communicator, he recently published “The Edge of Life” (2015), and “Sugar, Rum and Tobacco: Taxes and Public Health in New Zealand” with Lisa Marriott in 2017.
Our major scientific discovery that mitochondrial genes move to tumour cells without mitochondrial DNA has challenged a central dogma in cell biology that genes are constrained within cells and partition only during cell division. Acquisition of mitochondria from normal body cells restores tumour forming ability in breast cancer and melanoma models by enabling mitochondrial respiration.
This discovery has opened doors that will drive our research programme in new directions over the next decade. While exploring the difference in gene expression between breast cancer cells with and without mitochondrial DNA, we discovered that the mitochondrial genome is required for expression of several nuclear immune and stress response genes. Although similar stress response genes were observed in our melanoma and brain tumour models, the immune response genes were tumour type specific. This novel finding will allow us to determine how different tumours have evolved to hijack immune cells and other normal tissue cells for their own benefit, allowing tumour progression, immune escape and metastasis. This new research frontier has identified new targets for the development of novel cancer therapies, and is anticipated to lead to improved cancer immunotherapy.
We have found that mitochondrial transfer between cells also occurs in a brain tumour model raising profound questions about how the brain manages energy production in the central and peripheral nervous systems. Using our brain tumour model we will explore mitochondrial movement from normal brain cells to brain tumour cells and between normal brain cells. We will also determine how developing brain tumours control anti-tumour immune responses, a field that is in its infancy.
Since 2011, the discovery culture of the Cancer Cell Biology Group has become increasingly an internationally collaborative venture with Prof Jiri Neuzil, who holds positions at Griffith University, Gold Coast, and BIOCEV Biotechnology Institute, Prague West, and with Dr Lan-feng Dong at Griffith University. These collaborations have resulted in several high impact and highly cited publications, the most recent involving 15 research Institutions worldwide from eight different countries. In Wellington our small group collaborates with Dr Melanie McConnell and her team at Victoria University, with Associate Professor Patries Herst, Radiation Therapy, University of Otago Wellington, and internally with Malaghan Institute scientists whose dendritic cell research has highlighted dramatic mitochondrial gene involvement.
The main focus of the Cancer Cell Biology Group’s research is discovery. It applies new knowledge and methodologies to cells, cell systems, and complex tissues and organs to the benefit of human diseases, with a particular emphasis on cancer and diseases involving altered energy metabolism.
Our vision is that better understanding of tumour cell biology, brain inflammation and anti-tumour immune responses will generate new knowledge that will lead to better management and treatment of cancer and the major neurological diseases, and enhance the well-being of our ageing population.
Grasso C, Field CS, Tang CW, Ferguson PM, J Compton B, Anderson RJ, Painter GF, Weinkove R, F Hermans I, Berridge MV (2020). Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma. Immunotherapy.
Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL (2020). High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985).
Neuzil J, Berridge MV (2019) Mitochondria break through cellular boundaries. Aging (Albany NY) 11(13):4308-4309
Neuzil J, Dong L, Berridge M (2019) Cancer’s thieving ways. Australasian Science May/June, 38-39
Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L (2019) Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells. Redox Biol 26:101220
Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metab 29(2):399-416.e10
Herst PM, Grasso C, Berridge MV (2018) Metabolic reprogramming of mitochondrial respiration in metastatic cancer. Cancer and Metastasis Reviews 37(4):643-653
Berridge MV, Herst PM, Rowe MR, Schneider R, McConnell MJ. (2018). Mitochondrial transfer between cells: Methodological constraints in cell culture and animal models. Anal Biochem.
Herst PM, Dawson, RH, Berridge MV (2018) Intercellular communication in Tumour Biology: A Role for Mitochondrial Transfer. Frontiers in Oncol 8:344
Bezawork-Geleta A, Wen H, Dong L, Yan B, Vider J, Boukalova S, Krobova L, Vanova K, Zobalova R, Sobol M, Hozak P, Novais SM, Caisova V, Abaffy P, Naraine R, Pang Y, Zaw T, Zhang P, Sindelka R, Kubista M, Zuryn S, Molloy MP, Berridge MV, Pacak K, Rohlena J, Park S, Neuzil J. (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nat Commun.
Book: Berridge M. The Edge of Life: Controversies and Challenges in Human Health. BWB Publishing, pp 1-118, September, 2015. Berridge M, Marriott L. Sugar, Rum & Tobacco: taxes and public health in New Zealand. BWB Publishing, pp1-110, August, 2017
Herst PM, Rowe MR, Carson GM, Berridge MV. (2017) Functional Mitochondria in Health and Disease. Front Endocrinol (Lausanne).
Dong L-F, Kovarova J, Bajzikova M, Bezawork-Geleta A, Svec D, Endaya B, Sachaphibulkij K, Coelho AR, Sebkova N, Ruzickova A, Tan AS, Kluckova K, Judasova K, Zamecnikova K, Rychtarcikova Z, Gopalan V, Andera L, Sobol M, Yan B, Pattnaik B, Bhatraju N, Truksa J, Stopka P, Hozak P, Lam A, Sedlacek, R, Oliveira P, Kubista M, Agrawal A, Dvorakova-Hortova K, Rohlena J, Berridge MV, Neuzil J (2017) Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells. eLife
Berridge MV, Neuzil J (2017) The mobility of mitochondria: intercellular trafficking in health and disease. Clinical and Experimental Pharmacology and Physiology.
Waghorne CL, Corkran HM, Hunt-Painter AA, Niktab E, Baty JW, Berridge MV, Munkacsi AB, McConnell MJ, Timmer MS, Stocker BL (2016) N,N-Bis(glycityl)amines as anti-cancer drugs. Bioorg Med Chem
Roth I, Campbell H, Rubio C, Vennin C, Wilson M, Wiles A, Williams G, Woolley A, Timpson P, Berridge MV, Fleming N, Baird M, Braithwaite A (2016) The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene
Grasso C, Anaka M, Hofmann O, Sompallae R, Broadley K, Hide W, Berridge MV, Cebon J, Behren A, McConnell MJ (2016) Iterative sorting of CD133+ and CD133- melanoma cells indicates two phenotypically distinct populations.BMC Cancer
Berridge MV, McConnell MJ, Grasso C, Bajzikova M, Kovarova J, Neuzil J (2016) Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches.Curr Opin Genetics Dev
Berridge MV, Schneider R, McConnell MJ (2016) Mitochondrial transfer from astrocytes to neurons following ischemic insult: guilt by association?Cell Metab
Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobo M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA.Cell Metab
Berridge MV, Dong L, Neuzil J (2015) Mitochondrial DNA in tumor initiation, progression and metastasis: role of horizontal mtDNA transfer.Cancer Res
Berridge MV, Grasso C, Neuzil J (2015) Mitochondrial genome transfer to tumour cells breaks the rules and establishes a new precedent in cancer biology. Mol Cell Oncol
Tan AS, Baty JW, Dong LF, Bezawork-Gelata A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M; Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K; Sachaphibulkij K, Rohlena J, Hozak P, Truska J, Eccles D, Haupt L, Griffiths L, Neuzil J, BerridgeMV (2015) Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA. Cell Metabolism.
Berridge MV, Dong L, Neuzil J. (2015) Mitochondrial DNA in tumour initiation, progression and metastasis: role of horizontal mtDNA transfer. Cancer Research (Invited Review accepted for publication).
Tan AS, Baty JW, Berridge MV (2014) The role of mitochondrial electron transport in tumorigenesis and metastasis. Biochim Biophys Acta
Herst PM, Berridge MV (2013) Cell hierarchy, metabolic flexibility and systems approaches to cancer treatment. Curr Pharm Biotechnol
Grasso C, Larsen L, McConnell M, Smith RA, Berridge MV (2013) Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport.J Med Chem
Matilainen H, Yu XW, Tang CW, Berridge MV, McConnell MJ (2012) Sphere formation reverses the metastatic and cancer stem cell phenotype of the murine mammary tumour 4T1, independently of the putative cancer stem cell marker Sca-1. Cancer Lett, 323:20-8
Meyer KJ, Singh AJ, Cameron A, Tan AS, Leahy DC, O'Sullivan D, Joshi P, La Flamme AC, Northcote PT, Berridge MV, Miller JH (2012) Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. Mar Drugs, 10:900-17
Broadley K, Larsen L, Herst PM, Smith RA, Berridge MV, McConnell MJ (2011) The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. J Cell Biochem, 112:1869-79
Herst PM, Howman RA, Neeson PJ, Berridge MV, Ritchie DS (2011) The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome. J Leukoc Biol, 89:51-5
Berridge MV, Herst PM, Tan AS (2010) Metabolic flexibility and cell hierarchy in metastatic cancer. Mitochondrion, 10:584-8
Berridge MV, Tan AS (2010) Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect. Rejuvenation Res, 13:139-41
Mulchin BJ, Newton CG, Baty JW, Grasso CH, Martin WJ, Walton MC, Dangerfield EM, Plunkett CH, Berridge MV, Harper JL, Timmer MS, Stocker BL (2010) The anti-cancer, anti-inflammatory and tuberculostatic activities of a series of 6,7-substituted-5,8-quinolinequinones. Bioorg Med Chem, 18:3238-51
Prata C, Grasso C, Loizzo S, Sega FV, Caliceti C, Zambonin L, Fiorentini D, Hakim G, Berridge MV, Landi L (2010) Inhibition of trans-plasma membrane electron transport: A potential anti-leukemic strategy. Leuk Res, 34:1630-5
Tan AS, Berridge MV (2010) Evidence for NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated quinone-dependent redox cycling via plasma membrane electron transport: A sensitive cellular assay for NQO1. Free Radic Biol Med. 48:421-9. Corrigendium, 48:978
Appleton DR, Chuen CS, Berridge MV, Webb VL, Copp BR (2009) Rossinones A and B, biologically active meroterpenoids from the Antarctic ascidian, Aplidium species. J Org Chem, 74:9195-8
Berridge MV, Herst PM, Lawen A (2009) Targeting mitochondrial permeability in cancer drug development. Mol Nutr Food Res, 53:76-86
Berridge MV, Morre DJ (2009) Plasma membrane redox and cancer drug development. Preface. Biofactors 34:181-2
Herst PM, Davis JE, Neeson P, Berridge MV, Ritchie DS (2009) The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica 94:928-34
Tan AS, Berridge MV (2009) Differential effects of redox-cycling and arylating quinones on trans-plasma membrane electron transport. Biofactors 34:183-90
Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Landi L, Prata C, Berridge MV, Grasso C, Fiebig H-H, Kelter G, Burger AM, Kunkel MW (2008) Antitumor activity of bis-indole derivatives. J Med Chem, 51:4563-70
Chia EW, Pearce AN, Berridge MV, Larsen L, Perry NB, Sansom CE, Godfrey CA, Hanton LR, Lu G-L, Walton M, Webb VL, Copp BR, Harper JL (2008) Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis. Bioorg Med Chem, 16:9432-42
Herst PM, Hesketh EL, Ritchie DS, Berridge MV (2008) Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. Leuk Res, 32:327-33
Herst PM, Perrone GG, Dawes IW, Bircham PW, Berridge MV (2008) Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Res 8:897-905
Pearce AN, Chia EW, Berridge MV, Maas EW, Page MJ, Harper JL, Webb VL, Copp BR (2008) Orthidines A - E, tubastrine, 3,4-dimethoxyphenethyl-b-guanidine and 1,14-sperminedihomovanillamide: potential anti-inflammatory alkaloids isolated from the New Zealand ascidian Aplidium orthium that act as inhibitors of neutrophil respiratory burst. Tetrahedron 64:5748-55
Herst PM, Berridge MV (2007) Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochim Biophys Acta, 1767:170-7
Herst PM, Petersen T, Jerram P, Baty J, Berridge MV (2007) The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Biochem Pharmacol, 74:1587-95
McConnell MJ, Licht JD (2007) The PLZF Gene of t(11;17)-associated APL. Curr Top Microbiol Immunol, 313:31-48
Pearce AN, Berridge MV, Harper JL, Maas EW, Perry NB, Webb VL, Copp BR (2007) Anti-inflammatory agents from New Zealand marine organisms. Chem NZ, 71:47-9
Pearce AN, Chia EW, Berridge MV, Clark GR, Harper JL, Larsen L, Maas EW, Page MJ, Perry NB, Webb VL, Copp BR (2007) Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis. J Nat Prod, 70:936-40
Pearce AN, Chia EW, Berridge MV, Maas EW, Page MJ, Webb VL, Harper JL, Copp BR (2007) E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n sp. J Nat Prod 70:111-3
Rish KR, Swartzlander R, Sadikot TN, Berridge MV, Smith A (2007) Interaction of heme and heme-hemopexin with an extracellular oxidant system used to measure cell growth-associated plasma membrane electron transport. Biochim Biophys Acta, 1767:1107-17
Sansom CE, Larsen L, Perry NB, Berridge MV, Chia EW, Harper JL, Webb VL (2007) An anti-proliferative bis-prenylated quinone from the New Zealand brown alga Perithalia capillaris. J Nat Prod, 70:2042-4
Copp BR, Pearce AN, Denny WA, Berridge MV, Harper JL, Perry NB, Larsen L, Godfrey CA (2006) "Anti-inflammatory compounds" Patent PCT/NZ2005/000246, published as WO06/031134
Herst PM, Berridge MV (2006) Plasma membrane electron transport: a new target for cancer drug development. Invited Review. Curr Mol Med, 6:895-904
Herst PM, Tan AS, Berridge MV (2006) The cell membrane as a target for cancer drug development: leukaemia cell survival and growth depends on plasma membrane electron transport (PMET). Exp Hematol, 34:67
Berridge MV, Herst PM, Tan AS (2005) Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Ann Rev 11:127-52
Herst PM, Levine DM, Berridge MV (2005) Mitochondrial gene knockout HL60rho0 cells show preferential differentiation into monocytes/macrophages. Leuk Res 29:1163-70
McNamara CE, Larsen L, Perry NB, Harper JL, Berridge MV, Chia EW, Kelly M, Webb VL (2005) Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf.cristagalli. J Nat Prod, 68:1431-3
Scarlett D-JG, Herst PM, Berridge MV (2005) Multiple proteins with single activities or a single protein with multiple activities: the conundrum of the cell surface NADH oxidoreductase(s). Biochim Biophys Acta - Bioenerg, 1708:108-19
Berridge MV, Scarlett DJ (2004) Plasma membrane electron transport: A common theme linking inflammation, cellular defense against stress and energy metabolism. NZ BioScience, 13:14-16
Herst PM, Tan AS, Scarlett D-J, Berridge MV (2004) Cell surface oxygen consumption by mitochondrial gene-knockout cells. Biochim Biophys Acta Bioenerg, 1656:79-87
Kansara M, Berridge MV (2004) Hemopoietic cell transformation is associated with failure to down-regulate glucose uptake during the G2/M phase of the cell cycle. Exp Cell Res, 293:321-30
Kansara M, Berridge MV (2004) Oncogenes modulate cell sensitivity to apoptosis induced by glucose deprivation. Anticancer Res, 24:2503-10
Miller JH, Rouwe B, Gaitanos TN, Hood KA, Crume KP, Backstrom BT, La Flamme AC, Berridge MV, Northcote PT (2004) Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells. Apoptosis, 9:785-96
Scarlett DJ, Herst P, Tan A, Prata C, Berridge M (2004) Mitochondrial gene-knockout (p0) cells: A versatile model for exploring the secrets of trans-plasma membrane electron transport. BioFactors (in press)
Tan AS, Berridge MV (2004) Distinct trans-plasma membrane redox pathways reduce cell-impermeable dyes in HeLa cells. Redox Rep, 9:302-6
Keyzers RA, Northcote PT, Berridge MV, Clathriol B (2003) Clathirol B, A New 14b marine sterol from the New Zealand sponge Clathria lissosclera. Aust J Chem, 56:279-82
Appleton DR, Page MJ, Lambert G, Berridge MV, Copp BR. (2002) Kottamides A-D: A novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae. J Org Chem, 67:5402-4
Appleton DR, Sewell MA, Berridge MV, Copp BR (2002) A new biologically active malyngamide from a New Zealand collection of the sea hare Bursatella leachii. J Nat Prod, 65:630-31
Hood KA, West LM, Rouwe B, Northcote PT, Berridge MV, Wakefield StJ, Miller JH (2002) Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity. Cancer Res, 62:3356-60
Hood KA, Backstrom BT, West LM, Northcote PT, Berridge MV, Miller JH (2001) The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C. Anticancer Drug Des, 16:155-66
Hood KA, West LM, Northcote PT, Berridge MV, Miller JH (2001) Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine. Apoptosis, 6:207-19
Ahmed N, Berridge MV (2000) Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose decreases in human leukaemic cell lines but not in neutrophils. Pharmacol Toxicol, 86:114-21
Berridge MV, Tan AS (2000) High-capacity redox control at the plasma membrane of mammalian cells: trans-plasma membrane, cell surface and serum NADH-oxidases. Forum Review Article, Antiox Redox Signal, 2:231-42
Berridge MV, Tan AS (2000) Cell surface NAD(P)H-oxidase: relationship to trans-plasma membrane NADH-oxidoreductase and a potential source of circulating NADH-oxidase. Antiox Redox Signal, 2:277-88
Berridge MV, Ofman D, Pryor K, Robertson A, Slim GC, Tan AS (2000) Anti-inflammatory polysaccharides of the New Zealand green lipped mussel (Perna canaliculus). Glycobiology
Tan AS, Berridge MV (2000) Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents. J Immunol Methods, 238:59-68
Ahmed N, Anderson SM, Berridge MV (1999) Interleukin-3 induces apoptosis in a ras-transformed myeloid cell line. Apoptosis, 4:71-80
Ahmed N, Berridge MV (1999) Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line. Biochem Pharmacol, 57:387-96
Ahmed N, Berridge MV (1999) N-glycosylation of glucose transporter-1 (Glut-1) is associated with increased transporter affinity for glucose in human leukemic cells. Leuk Res, 23:395-401
Ahmed N, Berridge M (1998) Transforming oncogenes regulate glucose transport by increasing transporter affinity for glucose: contrasting effects of oncogenes and heat stress in a murine bone marrow-derived cell line. Life Sci, 63:1887-1903
Berridge M, Tan A (1998) Trans-plasma membrane electron transport: a cellular assay for NADH and NADPH-oxidase based on extracellular, superoxide-mediated reduction of the sulfonated tetrazolium salt WST-1. Protoplasma, 205:74-82
Tan AS, Ahmed N, Berridge MV (1998) Acute regulation of glucose transport after activation of human peripheral blood neutrophils by phorbol myristate acetate, fMLP, and granulocyte-macrophage colony-stimulating factor. Blood, 91:649-55
Ahmed N, Berridge MV (1997) Regulation of glucose transport by interleukin-3 in growth factor-dependent and oncogene-transformed bone marrow-derived cell lines. Leuk Res, 21:609-18
Ahmed N, Kansara M, Berridge MV (1997) Acute regulation of glucose transport in a monocyte-macrophage cell line: Glut-3 affinity for glucose is enhanced during the respiratory burst. Biochem J. 327:369-75
McCoy KD, Ahmed N, Tan AS, Berridge MV (1997) The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters. J Biol Chem, 272:17276-82
Berridge MV, Tan AS, McCoy KD, Kansara M, Rudert F (1996) CD95 (Fas/Apo-1)-induced apoptosis results in loss of glucose transporter function. J Immunol, 156:4092-9
Berridge MV, Horsfield JA, Tan AS (1995) Evidence that cell survival is controlled by interleukin-3 independently of cell proliferation. J Cell Physiol, 163:466-76
Berridge MV, Tan AS (1995) Interleukin-3 facilitates glucose transport in a myeloid cell line by regulating the affinity of the glucose transporter for glucose: involvement of protein phosphorylation in transporter activation. Biochem J, 305:843-51
Hilton CJ, Berridge MV (1995) Conserved region of the cytoplasmic domain is not essential for erythropoietin-dependent growth. Growth Factors, 12:263-76
Berridge MV, Tan AS (1993) Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys, 303:474-82
Berridge MV, Tan AS, Hilton CJ (1993) Cyclic adenosine monophosphate promotes cell survival and retards apoptosis in a factor-dependent bone marrow-derived cell line. Exp Hematol, 21:269-76
Berridge MV, Tan AS (1992) The protein kinase C inhibitor, calphostin C, inhibits succinate-dependent mitochondrial reduction of MTT by a mechanism that does not involve protein kinase C. Biochem Biophys Res Commun, 185:806-11
Dempster RP, Berridge MV, Harrison GB, Heath DD (1991) Echinococcus granulosus: development of an intermediate host mouse model for use in vaccination studies. Int J Parasitol, 21:549-54
Berridge MV, Fraser JK (1989) On the quest for lineage specific markers for the diagnosis of megakaryoblastic leukemia. Blood Cells. 15:278-83
Professor Mike Berridge has been awarded the distinguished Liley Medal from the Healt...