Dr Munoz-Erazo completed his PhD at the University of Sydney under Professor Nicholas King, investigating innate immune responses of human retinal pigment epithelium cells to West Nile virus (WNV) infection as well as establishing a murine model of retinal WNV infection.
His previous postdoctoral role was with Associate Professor Roslyn Kemp at the University of Otago exploring the tumour immune microenvironment in human colorectal cancer using high-dimensional microscopy technologies.
"My research interests revolve around understanding the pathogenesis and progression of disease. Investigating immune responses is a key approach. Consequently, I am interested in investigating how various types of leucocytes interact with each other and their microenvironments.
"New imaging technologies offer the ability to look at large number of markers, and I’m very enthusiastic about the possibilities these technologies offer to the field of immunology.
"My research projects within the Ronchese Lab will explore mechanisms involved in dendritic cell antigen presentation in allergy models, as well as characterising the T-cell subsets that they interact with. To do this, I’ll be employing microscopy imaging and especially new histocytometry analysis approaches; as both an exploratory and complementary technique with multiparameter flow cytometry."
Munoz-Erazo L, Shinko D, Schmidt AJ, Price KM (2022). Implementing High Dimensional Reduction Analysis on Histocytometric Data. Curr Protoc. 2(11):e586
Munoz-Erazo L, Schmidt AJ, Shinko D, Eccles DA, Price KM (2022). Creation of High-Dimensional Reduction Analysis-Compatible Histocytometry Files from Images of Densely-Packed Cells and/or Variable Stain Intensity. Curr Protoc. 2(5):e441
Mayer JU, Hilligan KL, Chandler JS, Eccles DA, Old SI, Domingues RG, Yang J, Webb GR, Munoz-Erazo L, Hyde EJ, Wakelin KA, Tang SC, Chappell SC, von Daake S, Brombacher F, Mackay CR, Sher A, Tussiwand R, Connor LM, Gallego-Ortega D, Jankovic D, Le Gros G, Hepworth MR, Lamiable O, Ronchese F (2021). Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization. Nat Immunol. 2021 Nov 18