Dr Kerry Hilligan

Dr Kerry Hilligan is an International Research Fellow in Prof. Franca Ronchese’s Immune Cell Biology Programme and is currently based in Dr. Alan Sher's lab at the National Institutes of Health in Bethesda, USA.

Kerry joined the Malaghan Institute in 2012 to undertake post-graduate research in the Immune Cell Biology Programme. Her research has centred around a rare population of innate immune cells, known as antigen-presenting cells (APC), that play vital role in initiating and shaping immune responses.

Research interests

"I am interested in understanding the innate immune pathways involved in initiating and shaping adaptive immune responses. I have a particular interest in antigen-presenting cell (APC) populations, which are known play an important role in dictating the outcome of immune responses. I am working to understand the mechanisms by which various APC subsets recognise and respond to material from different pathogens and allergens, and ultimately, regulate the function of effector immune cells. The aim of this research is to inform vaccine design and assist with therapeutic strategies for autoimmune and allergic diseases.

" I am currently investigating how the immunological history of an individual may shape the composition and function of their antigen-presenting cells (APC) compartment. I am using pre-clinical models to test the effects of various inflammatory and infectious stimuli on the developmental trajectory and functional capacity of APC populations in both the short- and long-term."

Research group

Publications

2021

Mayer JU, Hilligan KL, Chandler JS, Eccles DA, Old SI, Domingues RG, Yang J, Webb GR, Munoz-Erazo L, Hyde EJ, Wakelin KA, Tang SC, Chappell SC, von Daake S, Brombacher F, Mackay CR, Sher A, Tussiwand R, Connor LM, Gallego-Ortega D, Jankovic D, Le Gros G, Hepworth MR, Lamiable O, Ronchese F (2021). Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization. Nat Immunol. 2021 Nov 18

2020

Hilligan KL, Ronchese F (2020). Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses. Cell Mol Immunol. 17(6):587-599

Ronchese F, Hilligan KL, Mayer JU (2020). Dendritic Cells and the Skin Environment. Curr Opin Immunol. 64:56-62.

2019

R Blecher-Gonen, P Bost, KL Hilligan, E David, T Meir-Salame, B Cohen-Toth, E Roussel, JU Mayer, LM Connor, S Itzkovitz, B Schikowski, F Ronchese, I Amit, (2019). Single-Cell Analysis of Diverse Pathogen Responses Defines a Molecular Roadmap for Generating Antigen-Specific Immunity. Cell Syst. doi: 10.1016/j.cels.2019.01.001.

2017

LM Connor, S-C Tang, E Cognard, S Ochiai, KL Hilligan, SI Old, C Pellefigues, RF White, D Patel, AAT Smith, DA Eccles, O Lamiable, MJ McConnell and F Ronchese, (2017). Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles. J Exp Med. doi: 10.1084/jem.20160470

2016

KL Hilligan, LM Connor, AJ Schmidt and F Ronchese, (2016). Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant. PLoS ONE 11(7): e0158775. doi:10.1371/journal.pone.0158775.