24 August 2015
The world-first discovery in cell biology made by scientists based in New Zealand and Australia in 2015 might have been made a decade earlier if not for Hurricane Katrina; according to a researcher who watched as rising water and eventual power failure destroy his cell cultures at Tulane University New Orleans in late August 2005.
Scott Olson, now an Associate Professor at the University of Texas, contacted Professors Mike Berridge (Malaghan Institute) and Jiri Neuzil (Griffith University) to congratulate them on their publication in January 2015; pleased that despite the years, science had found a way through. His work was among the approximately 300 federally funded projects at New Orleans colleges and universities, cumulatively valued at more than $150 million that was set back by the destructive power of Katrina a decade ago.
Mike Berridge said of Scotts email contact, It was a wonderful gesture but typical of the scientific community. We are competitive of course, but ultimately if we advance something that may change the way we treat disease, the research world takes notice. Defective mitochondrial DNA is known to account for around 200 diseases and is implicated in many more.
Subsequent to their discovery this year Professors Berridge and Neuzil were invited to review their work on mitochondrial transfer between cells in the prestigious Cancer Research journal. As a consequence of the 2015 paper, the focus of mitochondrial shuttling between cells has shifted from an interesting cell culture observation to a silent and stealthy physiological phenomenon with potential relevance to development, human health and disease. Without mitochondria a cell typically dies. Mitochondria donation could become possible in the future to restore cell health, or starve, for example, a tumour cell of the energy required to grow.
Caption: The dark field image on the left highlights the transfer of fluorescent mitochondria. The bright field on the right has sufficient light to see the connecting nanotube.