At the University of Orleans, France, Dr Olivier Lamiable achieved his License degree, Master’s degree and PhD. Completed early 2010, his PhD focused on epigenetic regulation of the embryonic development of Drosophila melanogaster (the common fruit fly). His research identified and characterized protein partners of the ortholog of HMGB1 that are involved in this process. Following this, Dr Lamiable studied the antiviral responses of D. melanogaster at Institute de Biologie Moleculaire et Cellulaire in Strasbourg, France.
Dr Lamiable was drawn to the Malaghan Institute by the opportunity to transfer his skills into research more applicable to human health. In March 2016, he became a Postdoctoral Research Fellow in our Immune Cell Biology Programme, led by Professor Franca Ronchese, with a specific focus on allergies.
Allergies involve the immune system overreacting to harmless substances. Over a third of New Zealanders experience allergies in their lifetime, at differing levels of severity. These can range from minor inconveniences to life threatening conditions. While there are various drugs to manage symptoms, curative treatments for allergies do not yet exist.
I am interested in understanding the processes that begin an allergic reaction. I particularly focus on the genetic regulation of the immune system and how dendritic cells function in allergic reactions.
Alongside Professor France Ronchese and the Immune Cell Biology Group, we study dendritic cells, a rare cell population essential to immune responses. As a molecular immunologist, I combine immunology with molecular technologies and bioinformatics to explore what triggers these cells to mount an allergic response. If we can understand these mechanisms, we could potentially target them in new therapies.
This exciting project explores fundamentals of immunology and cell biology that could have a strong impact on global health and medicine. Allergy is a prominent disease in the developed world, with rates of incidence increasing but with no clear understanding why. Our projects aim to uncover the unknowns of allergies in order to answer these questions and discover new therapeutic targets.
Poyntz, HC, Jones A, Jauregui R, Young W, Gestin A, Mooney A, Lamiable O, Altermann E, Schmidt A, Gasser O, Weyrich L, Jolly CJ, Linterman MA, Le Gros G, Hawkins ED, Forbes-Blom E (2018) Genetic regulation of antibody responsiveness to immunization in substrains or BALB/c mice. Immunol & Cell Biol 97(1):39-53
Ochiai S, Jagot F, Kyle RL, Hyde E, White RF, Prout M, Schmidt AJ, Yamane H, Lamiable O, Le Gros G, Ronchese F (2018) Thymic stromal lymphopoietin drives the development of IL-13 + Th2 cells. PNAS USA 115(5)1033-1038
White R, Pellefigues C, Ronchese F, Lamiable O, Eccles D (2017) Investigation of chimeric reads using the MinION. F1000Research.
Connor LM, Lamiable O, Ronchese F (2017) Fetal dendritic cells give mum a break. Immunol Cell Biol.
Connor LM, Tang SC, Cognard E, Ochiai S, Hilligan K, Old S, Pellefigues C, White R, Patel D, Smith A, Eccles D, Lamiable O, McConnell M, Ronchese F (2017) Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles. J Exp Med.
Pellefigues C, Tang SC, Schmidt A, White RF, Lamiable O, Connor LM, Ruedl C, Dobrucki J, Le Gros G, Ronchese F (2017) Toll-Like Receptor 4, but Not Neutrophil Extraceullular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis. Front Immunol 8:1575
Lamiable O, Meignin C, Imler JL (2016) WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity. Fly (Austin)
Lamiable O, Arnold J, de Faria IJ, Olmo RP, Bergami F, Meignin C, Hoffmann JA, Marques JT, Imler JL (2016) Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity. J Virol.
Lamiable O, Kellenberger C, Kemp C, Troxler L, Pelte N, Boutros M, Marques JT, Daeffler L, Hoffmann J.A, Roussel A, Imler JL (2016) The cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila. PNAS.
Chtarbanova S, Lamiable O, Lee KZ, Galiana D, Troxler L, Meignin C, Hetru C, Hoffmann JA, Daeffler L, Imler JL (2014) Drosophila C virus systemic infection leads to intestinal obstruction. J Virol.
Lamiable O, Imler JL (2014) Induced antiviral innate immunity in Drosophila. Curr Opin Microbiol.
Petrillo JE, Venter PA, Short JR, Gopal R, Deddouche S, Lamiable O, Imler JL, Schneemann A (2013) Cytoplasmic granule formation and translational inhibition of nodaviral RNAs in the absence of the double-stranded RNA binding protein B2. J Virol.
Lamiable O, Rabhi M, Peronnet F, Locker D, Decoville M (2010) Rm62, a DEAD box RNA helicase, complexes with DSP1 in Drosophila embryo. Genesis.