Dr Jeffry Tang completed his PhD at the School of Chemical Sciences at the University of Auckland in 2018, under the supervision of Associate Professor Robert F Anderson and Professor Laurence Melton. His thesis investigated the molecular mechanisms by which bioavailable phenolic metabolites derived from the extensive metabolism of blueberry polyphenols could alleviate oxidative stress-induced endothelial dysfunction.
Following his PhD, he worked at the Centre for Free Radical Research at the University of Otago Christchurch, where he studied the relationships between the levels of a variety of protein and small-molecule markers of oxidative stress, with aspects of human health and development.
Jeffry is a postdoctoral research fellow in the Gasser Laboratory.
Research interests
"The limited bioavailability and extensive metabolism of many dietary compounds have piqued my interests in investigating how different metabolites generated during the first-pass and microbial metabolisms of these compounds can benefit immune cell function. I am particularly interested in better understanding how these metabolites could impact immune tolerance towards normal intestinal flora, while simultaneously boosting responses against pathogens and other stimuli deleterious to immune homeostasis."
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Publications
2024
2023
Belkina AC, Roe CE, Tang VA, Back JB, Bispo C, Conway A, Chakraborty U, Daniels KT, de la Cruz G, Ferrer-Font L, Filby A, Gravano DM, Gregory MD, Hall C, Kukat C, Mozes A, Ordoñez-Rueda D, Orlowski-Oliver E, Pesce I, Porat Z, Poulton NJ, Reifel KM, Rieger AM, Sheridan RTC, Van Isterdael G, Walker RV (2023). Guidelines for establishing a cytometry laboratory. Cytometry A. 2023 Nov 8
Tang JS, Stephens R, Li Y, Cait A, Gell K, Faulkner S, Grooby A, Herst PM, O'Sullivan D, Gasser O (2023). Polyphenol and glucosinolate-derived AhR modulators regulate GPR15 expression on human CD4+ T cells. J Nutr Biochem. 122:109456
Mules TC, Lavender B, Maclean K, Vacca F, Noble SL, Yumnam B, Te Kawa T, Cait A, Tang J, O'Sullivan D, Gasser O, Stanley J, Le Gros G, Camberis M, Inns S (2023). Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial. Inflamm Bowel Dis. 2023 Jun 15
2022
Tang JS, Cait A, White RM, Arabshahi HJ, O’Sullivan D and Gasser O (2022). MR1-dependence of unmetabolized folic acid side-effects. Front. Immunol. 13:946713
Farrand K, Holz LE, Ferrer-Font L, Wilson MD, Ganley M, Minnell JJ, Tang CW, Painter GF, Heath WR, Hermans IF, Burn OK (2022). Using Full-Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue-Specific Preparation Protocols. Curr Protoc. 2(7):e482.
Burn OK, Farrand K, Pritchard T, Draper S, Tang CW, Mooney AH, Schmidt AJ, Yang SH, Williams GM, Brimble MA, Kandasamy M, Marshall AJ, Clarke K, Painter GF, Hermans IF, Weinkove R (2022). Glycolipid-peptide conjugate vaccines elicit CD8+ T-cell responses and prevent breast cancer metastasis. Clin Transl Immunology. 11(7):e1401
2021
Cait A, Mooney A, Poyntz H, Shortt N, Jones A, Gestin A, Gell K, Grooby A, O’Sullivan D, Tang JS, Young W, Thayabaran D, Sparks J, Ostapowicz T, Tay A, Poppitt SD, Elliott S, Wakefield G, Parry-Strong A, Ralston J, Beasley R, Weatherall M, Braithwaite I, Forbes-Blom E and Gasser O (2021). Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine. Front. Immunol. 12:765528
Tang JS, Cait A, Li Y, Abolins-Thompson H, Gell K, Herst PM, O'Sullivan D, Gasser O (2021). Practical Approach To Explore the Effects of Polyphenols on Aryl Hydrocarbon Receptor Regulated Immune Function. J Agric Food Chem. 69(31):8625-8633
Gasser O, Tang J, Cait A (2021). Commentary on "properties and reactivity of the folic acid and folate photoproduct 6-formylpterin" by Goossens et al. [Free radic. Biol. Med. (2021) May 6;S0891-5849(21)00283-5]. Free Radic Biol Med. 2021 Jul 8:S0891-5849(21)00405-6