Dr Melanie McConnell received a PhD in biochemistry from the University of Otago, working to understand regulation of gene expression during kidney development.
After a postdoctoral fellowship comparing normal and leukaemia blood cell development in the Ruttenberg Cancer Center at Mount Sinai School of Medicine in New York, she joined the faculty of the Division of Medicine at Mount Sinai, in the Department of Hematology and Oncology. Her research focused on the interaction between gene expression and cell biology during exposure of leukaemic cells to novel therapeutic agents, both in the laboratory and in patients.
On her return to New Zealand, Melanie established the Cell Survival Research Group at the Malaghan Institute. In 2013 she took up a position at the School of Biological Sciences at Victoria University but continues to work closely with the Institute.
Fabre MS, Stanton NM, Slatter TL, Lee S, Senanayake D, Gordon RMA, Castro ML, Rowe MR, Taha A, Royds JA, Hung N, Melnick AM, McConnell MJ (2020). The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. PLoS One. 15(4):e0231470
Berridge MV, Herst PM, Rowe MR, Schneider R, McConnell MJ (2018) Mitochondrial transfer between cells: methodological constraints in cell culture and animal models. Analytical Biochem 552: 75-80
Connor LM, Tang SC, Cognard E, Ochiai S, Hilligan KL, Old SI, Pellefigues C, White RF, Patel D, Smith AA, Eccles DA, Lamiable O, McConnell MJ, Ronchese F (2017) Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles. J Exp Med.
Berridge MV, McConnell MJ, Grasso C, Bajzikova M, Kovarova J, Neuzil J (2016) Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches. Curr Opin Genetics Dev
Berridge MV, Schneider R, McConnell MJ (2016) Mitochondrial transfer from astrocytes to neurons following ischemic insult: guilt by association? Cell Metab
Grasso C, Anaka M, Hofmann O, Sompallae R, Broadley K, Hide W, Berridge MV, Cebon J, Behren A, McConnell MJ (2016) Iterative sorting of CD133+ and CD133- melanoma cells indicates two phenotypically distinct populations. BMC Cancer
Waghorne CL, Corkran HM, Hunt-Painter AA, Niktab E, Baty JW, Berridge MV, Munkacsi AB, McConnell MJ, Timmer MS, Stocker BL (2016) N,N-Bis(glycityl)amines as anti-cancer drugs. Bioorg Med Chem
Castro LM, McConnell MJ, Herst PM (2014) Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free Radic Biol Med & Frontiers in Oncology
McConnell MJ, Herst PM (2014) Ascorbate combination therapy: new tool in the anticancer toolbox? Sci Transl Med
Authier A, Farrand KJ, Broadley KWR, Stone S, Hunn MK, Ancelet LR, McConnell MJ, Hermans IF. (2014) Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells. Int J Cancer.
Castro LM, McConnell MJ, Herst PM. (2014) Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free.Radic.Biol.Med.
Grasso C, Fabre MS, Collis SV, Castro ML, Field CS, Schleich N, McConnell MJ, Herst PM. (2014). Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Front Oncol.
Grasso C, Larsen L, McConnell M, Smith RA, Berridge MV (2013) Anti-leukemic activity of ubiquinone-based compounds targeting trans-plasma membrane electron transport. J Med Chem
Herst PM, Broadley KW, Harper JL, McConnell MJ (2012) Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest. Free Radic Biol Med
Hunn MK, Farrand KJ, Broadley KW, Weinkove R, Ferguson P, Miller RJ, Field CS, Petersen T, McConnell MJ, Hermans IF (2012) Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma. Clin Cancer Res.
Klionsky DJ et al (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy.
Matilainen H, Yu XW, Tang CW, Berridge MV, McConnell MJ (2012) Sphere formation reverses the metastatic and cancer stem cell phenotype of the murine mammary tumour 4T1, independently of the putative cancer stem cell marker Sca-1. Cancer Lett.
Robinson M, McConnell MJ, Le Gros G (2012) How epigenetic imprinting contributes to stabilizing the Th2 phenotype. Immunol Cell Biol.
Broadley KW, Hunn MK, Farrand KJ, Price KM, Grasso C, Miller RJ, Hermans IF, McConnell MJ (2011) Side population is not necessary or sufficient for a cancer stem cell phenotype in glioblastoma multiforme. Stem Cells.
Broadley K, Larsen L, Herst PM, Smith RA, Berridge MV, McConnell MJ (2011) The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. J Cell Biochem.
Berkofsky-Fessler W, Buzzai M, Kim M, Fruchtman S, Najfeld V, Min DJ, Costa F, Bischoff J, Soares M, McConnell M, Zhang W, Levine R, Gilliland DG, Carogero R, Licht JD (2010) Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F. Clin Cancer Res.
Osmond TL, Broadley KW, McConnell MJ (2010) Glioblastoma cells negative for the anti-CD133 antibody AC133 express a truncated variant of the CD133 protein. Int J Mol Med.
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD (2009) Comprehensive genomic screens identify a role for PLZF-RARa as a positive regulator of cell proliferation via direct Regulation of c-MYC. Blood.
Fandy TE, Herman JG, Kerns P, Jiemjit A, Sugar EA, Choi S, Yang AS, Aucott T, Dauses T, Odchimar-Reissig R, Licht JD, McConnell MJ, Nasrallah C, Kim MKH, Zhang W, Sun Y, Murgo A, Espinoza-Delgado I, Oteiza K, Owoeye I, Silverman LR, Gore SD, Carraway H (2009) Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood.
Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Paolo Pandolfi P, Licht JD, Williams BRG (2009) Promyelocytic leukemia zinc finger protein regulates interferon-mediated antiviral innate immunity. Immunity.
van Panhuys N, Le Gros G, McConnell MJ (2008) Epigenetic regulation of Th2 cytokine expression in atopic diseases. Tissue Antigens.
Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD, Haddad GG (2007) Novel functional interaction between Na /H exchanger 1 and tyrosine phosphatase SHP-2. Am J Physiol: Regulatory, Comparative and Integrative Physiology.
McConnell MJ, Licht JD (2007) The PLZF gene of t(11;17)-associated APL. Curr Topics Microbiol Immunol.
Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A (2005) Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol.
Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (2004) The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT. Blood.
McConnell MJ, Chevallier N, Berkofsky-Fessler W, Giltnane JM, Malani RB, Staudt LM, Licht JD (2003) Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. Mol Cell Biol.
Topisirovic I, Guzman ML, McConnell MJ, Licht JD, Culjkovic B, Neering SJ, Jordan CT, Borden KL (2003) Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Mol Cell Biol.
Dai MS, Chevallier N, Stone S, Heinrich MC, McConnell M, Reuter T, Broxmeyer HE, Licht JD, Lu L, Hoatlin ME (2002) The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. J Biol Chem.
Ward JO*, McConnell MJ*, Carlile GW, Pandolfi PP, Licht JD, Freedman LP (2001) The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor. Blood.
Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000) AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. Blood.
McConnell MJ, Cunliffe HE, Chua LJ, Ward TA, Eccles MR (1997) Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene.
MEDIA RELEASE by AINSLIE TALBOT from the University of Otago. Recent research by the ...
Senior Malaghan Institute scientist Dr Melanie McConnell has built an entire researc...
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