Multiple Sclerosis Group Publications
Anne La Flamme publications- research undertaken in Dr La Flamme's laboratory at VUW
Robinson MJ, Ronchese F, Miller JH, La Flamme AC (2010) Paclitaxel inhibits killing by murine cytotoxic T lymphocytes in vivo but not in vitro. Immunol Cell Biol, 88:291-6
Manivannan B, Rawson P, Jordan TW, Secor WE, La Flamme AC (2010) Differential patterns of liver proteins in experiemental murine hepatosplenic schistosomiasis. Infect Immun, 78:618-28
Crume KP, O'Sullivan D, Miller JH, Northcote PT, La Flamme AC (2009) Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A. J Leukoc Biol, 86:949-58
Thomas Bäckström publications at MIMR
Dickgreber N, Stoitzner P, Bai Y, Price KM, Farrand KJ, Manning K, Angel CE, Dunbar PR, Ronchese F, Fraser JD, Bäckström BT, Hermans IF (2009) Targeting antigen to MHC class II molecules promotes cross-presentation and enhances immunotherapy. J Immunol, 182:1260-9
Keating P, O'Sullivan D, Tierney JB, Kenwright D, Miromoeini S, Mawasse L, Brombacher F, La Flamme AC (2009) Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement. Immunol Cell Biol, 87:534-45
Manivannan B, Rawson P, Jordan TW, Secor WE, La Flamme AC (2009) Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis. Infect Immun, [Epub ahead of print 23 Nov 2009]
Robinson MJ, Ronchese F, Miller JH, La Flamme AC (2009) Paclitaxel inhibits killing by murine cytotoxic T lymphocytes in vivo but not in vitro. Immunol Cell Biol, [Epub ahead of print 8 Dec 2009]
Tierney JB, Kharkrang M, La Flamme AC (2009) Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis. Immunol Cell Biol, 87:235-40
Chan J, Ban EJ, Chun KH, Wang S, Backstrom BT, Bernard CC, Toh BH, Alderuccio F (2008) Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease. J Immunol, 181:7571-80
Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, Ahrens R, Seidu L, McKenzie A, Strait R, Finkelman FD, Foster PS, Matthaei KI, Rothenberg ME, Hogan SP (2008) IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med, 205:897-913 & Nature Rev Immunol, 8:321
Bäckström BT, Brockelbank JA, Rehm BH (2007) Recombinant Escherichia coli produces tailor-made biopolyester granules for applications in fluorescence activated cell sorting: functional display of the mouse interleukin-2 and myelin oligodendrocyte glycoprotein. BMC Biotechnol, 7:3
Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK (2007) Nat Med, 13:423-31
McNeill A, Spittle E, Bäckström BT (2007) Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61. Scand J Immunol, 65:63-9
Petersen TR, Lata R, Spittle E, Bäckström BT (2007) A chimeric TCR-beta chain confers increased susceptibility to EAE. Mol Immunol, 44:3473-81
La Flamme AC, Harvie M, McNeill A, Goldsack L, Tierney JB, Bäckström BT (2006) Fcgamma receptor-ligating complexes improve the course of experimental autoimmune encephalomyelitis by enhancing basal Th2 reponses. Immunol Cell Biol, 84:522-9
Weir C, McNeill A, Hook S, Harvie M, La Flamme AC, Le Gros G, Bäckström BT (2006) Critical role of preproenkephalin in experimental autoimmune encephalomyelitis. J Neuroimmunol, 179:18-25
Kemp RA, Bäckström BT, Ronchese F (2005) The phenotype of type 1 and type 2 CD8+ T cells activated in vitro is affected by culture conditions and correlates with effector activity. Immunol, 115:315-24
McNeill A, Lata R, Bäckström BT (2005) Immunotherapy of EAE. Tissue Antigens, 66:409
Petersen T, Jasim A, Tuncel J, Bäckström BT (2005) Effect of enhanced TCR and co-stimulatory signalling on autoimmunity. Tissue Antigens, 66:28
Heinemann L, Dillon S, Crawford A, Bäckström BT, Hibma MH (2004) Flow cytometric quantitation of the protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model. J Virol Methods, 117:9-18
Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R (2004) Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci U S A, 101:12646-12651
La Flamme AC, Canagasabey K, Harvie M, Bäckström BT (2004) Schistosomiasis protects against multiple sclerosis. Mem Inst Oswaldo Cruz, 99:33-36
McNeill A, Kastrup J, Bäckström BT (2004) A simplified cytokine immunoassay using magnetic polymer particles. Scand J Immunol, 60:287-291
Miller JH, Rouwe B, Gaitanos TN, Hood KA, Crume KP, Bäckström BT, La Flamme AC, Berridge MV, Northcote PT (2004) Peloruside A enhances apoptosis in H-ras-transformed cells and is cytotoxic to proliferating T cells. Apoptosis, 9:785-796
Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BT (2004) Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol, 34:165-173
Petersen TR, Gülland S, Bettelli E, Kuchroo V, Palmer E, Bäckström BT (2004) A chimeric T cell receptor with super-signaling properties. Int Immunol, 16:889-894
Bhatnagar A, Gulland S, Bascand M, Palmer E, Gardner TG, Kearse KP, Bäckström BT (2003) Mutational analysis of conserved amino acids in the T cell receptor alpha-chain transmembrane region: a critical role of leucine 112 and phenylalanine 127 for assembly and surface expression. Mol Immunol, 39:953-963
La Flamme AC, Ruddenklau K, Bäckström BT (2003) Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immunity, 71:4996-5004
Matthews K, Leong CM, Baxter L, Inglis E, Yun K, Bäckström BT, Doorbar J, Hibma M (2003) Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin. J Virol, 77:8378-8385
Weir C, Bernard CC, Bäckström BT (2003) IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis. Int Immunol, 15:1283-1289
Nicolson K, Freland A, Weir C, Delahunt B, Flavell RA, Bäckström BT (2002) Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2. Int Immunol, 14:849-856
Weir CR, Nicolson K, Bäckström BT (2002) Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptide. Immunol Cell Biol, 80:14-20
Hood KA, Bäckström BT, West LM, Northcote PT, Berridge MV, Miller JH (2001) The novel cytotoxic sponge metabolite peloruside A, structurally similar mvto bryostatin-1, has unique bioactivity independent of protein kinase C. Anticancer Drug Des, 16:155-166
Shelton JG, Gulland S, Nicolson K, Kearse KP, Bäckström BT (2001) Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits. Mol Immunol, 38:259-265
Weir C, Nicolson K, Bäckström BT (2001) Dendritic cells presenting a self-peptide induce experimental autoimmune encephalomyelitis in naïve mice. Abstract in Scand J Immunol, 54:Supplement 1:64
Bäckström BT, Nicolson K, Cotton C (1999) The Role of NK-T Cells in Experimental Autoimmune Encephalomyelitis. Abstract in Scand J Immunol, 50:331
Bäckström BT, Muller U, Hausmann B, Palmer E (1998) Positive selection through a motif in the ab T cell receptor. Science, 281:835-838
Dietrich J, Bäckström BT, Lauritsen JP, Kastrup J, Christensen, von Bulow F, Palmer E, Geisler C (1998) The phosphorylation state of CD3gamma influences T cell responsiveness and controls T cell receptor cycling. J Biol Chem, 273:24232-24238
Bäckström BT, Hausmann BT, Palmer E (1997) Signaling efficiency of the T cell receptor controlled by a single amino acid in the b chain constant region. J Exp Med, 186:1933-1938
Bäckström BT, Rubin B, Peter A, Tiefenthaler G, Palmer E (1997) T cell receptor a-chain tail is required for protein kinase C-mediated down-regulation, but not for signaling. Eur J Immunol 27:1433-1441.
