Asthma & Parasitic Diseases Group Publications
Forbes E, van Panhuys N, Min B, Le Gros G (2010) Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses. Immunol Cell Biol, 88:240-3 [Epub ahead of print 15 Dec 2009]
Douwes J, Cheng S, Travier N, Cohet C, Niesink A, McKenzie J, Cunningham C, Le Gros G, von Mutius E, Pearce N (2008) Farm exposure in utero may protect against asthma, hay fever and eczema. Eur Respir J, 32:603-11
Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, Ahrens R, Seidu L, McKenzie A, Strait R, Finkelman FD, Foster PS, Matthaei KI, Rothenberg ME, Hogan SP (2008) IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med, 205:897-913 & Nature Rev Immunol, 8:321
Le Gros G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE (2008) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J Immunol, 181:2943-51
Shen T, Kim S, Do JS, Weng L, Lantz C, Urban JF, Le Gros G, Min B (2008) T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival. Int Immunol 20:1201-9
van Panhuys N, Le Gros G, McConnell MJ (2008) Epigenetic regulation of Th2 cytokine expression in atopic diseases. Tissue Antigens, 72:91-7
van Panhuys N, Tang S-C, Prout M, Camberis M, Scarlett D, Roberts J, Hu-Li J, Paul WE, Le Gros G (2008) In vivo studies fail to reveal a role for IL-4 or STAT6 signalling in Th2 lymphocyte differentiation. Proc Natl Acad Sci USA, 105:12423-8
Wang L, van Panhuys N, Hu-Li J, Kims S, Le Gros G, Min B (2008) Blimp-1 induced by IL-4 plays a critical role in suppressing IL-2 production in activated CD4 T cells. J Immunol, 181:5249-56
Douwes J, Travier N, Huang K, Cheng S, McKenzie J, Le Gros G, von Mutius E, Pearce N (2007) Lifelong farm exposure may strongly reduce the risk of asthma in adults. Allergy, 62:1158-65
Oh K, Shen T, Le Gros G, Min B (2007) Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood, 109:2921-7
Harris NL, Watt V, MacLenachan S, Diehl S, Marsland BJ, Rincon M, Le Gros G (2006) Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation. Microbes Infect 8:232-7
Min B, Le Gros G, Paul WE (2006) Basophils: a potential liaison between innate and adaptive immunity. Allergol Int, 55:99-104
Douwes J, Le Gros G, Gibson P, Pearce N (2005) On the hygiene hypothesis: Regulation down, up, or sideways? Correspondence in J Allergy Clin Immunol, 115:1325-1326
Harris NL, Holloway J, Fitzharris P, McDonald M, Camberis M, Fazekas de St Groth B, Ronchese F, Le Gros G (2005) Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation. Immunol Cell Biol, 83:490-7
Marsland BJ, Camberis M, Le Gros G (2005) Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response. Immunol Cell Biol, 83:40-7
van Panhuys N, Perret R, Prout M, Ronchese F, Le Gros G (2005) Effector lymphoid tissue and its crucial role in protective immunity. Trends Immunol, 26:242-7
Douwes J, Le Gros G, Gibson P, Pearce N (2004) Can bacterial endotoxin exposure reverse atopy and atopic disease? J Allergy Clin Immunol, 114:1051-4
Marsland BJ, Harris NL, Camberis M, Kopf M, Hook SM, Le Gros G (2004) Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells. Proc Natl Acad Sci USA, 101:6116-21
Marsland BJ, Kopf M, Le Gros G (2004) Viral infection and allergy. Letter to Nature Immunol. 5:865
Marsland BJ, Le Gros G (2004) CD8+ T cells and immunroregulatory networks in asthma. Springer Semin Immunopathol, 25:311-23
Marsland BJ, Scanga CB, Kopf M, Le Gros G (2004) Allergic airway inflammation is exacerbated during acute influenza infection and correlates with increased allergen presentation and recruitment of allergen-specific T-helper type 2 cells. Clin Exp Allergy, 34:1299-306
Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, Urban JF, Dvorak AM, Finkelman FD, Le Gros G, Paul WE (2004) Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med, 200:507-17
Sayers I, Severn W, Scanga C, Hudson J, Le Gros G, Harper JL (2004) Suppression of allergic airway disease using mycobacterial lipoglycans. J Allergy Clin Immunol, 114:302-9
Singh-Gill G, Larsen DS, Jones JD, Severn WB, Harper JL (2004) Synthetic molecules having immune activity (2004). PCT /NZ2004/000293 (in press)
Hook S, Camberis M, Prout M, Le Gros G (2003) Absence of preproenkephalin increases the threshold for T cell activation. J Neuroimmunol, 140:61-8
Sayers I, LeGros G, Harper JL (2003) From hygiene hypothesis to novel allergic asthma therapeutics. Cur Med Chem-Anti-Inflamm Anti-Allergy Agents, 2:143-155
Beasley R, Shirtcliffe P, Harper JL, Holt S, Le Gros G (2002) Mycobacterium-based vaccines for the prevention of allergic disease: a progress report. Clin Exp Allergy, 32:1128-30
Camberis M, Le Gros G, Urban Jr J (2002) Animal models of Nippostronglyus brasiliensis and Heligmosomoides polygyrus. Curr Protocols Immunol, in press
Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rincon M (2002) c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med, 195:811-23
Guo L, Hu-Li J, Zhu J, Watson CJ, Difilippantonio MJ, Pannetier C, Paul WE. (2002) In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc Natl Acad Sci USA, 99:10623-8
Harris N, Watt V, Ronchese F, Le Gros G (2002) Differential T cell function and fate in lymph node and non-lymphoid tissues. J Exp Med, 195:317-26
Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE (2002) Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity, 16:733-44
Harris N, Prout M, Peach RJ, Fazekas de St Groth B, Ronchese F (2001) CD80 costimulation is required for Th2 cell cytokine production but not for antigen-specific accumulation and migration into the lung. J Immunol, 166:4908-4914
Shirtcliffe PM, Easthope SE, Cheng S, Weatherall M, Tan PL, Le Gros G, Beasley R (2001) The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma. Am J Respir Crit Care Med 163:1310-4
Conze D, Lumsden J, Enslen H, Davis RJ, Le Gros G, Rincon M (2000) Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus. Mol Immunol, 37:503-13
Holloway JW, Dunbar R, Riley G, Sawyer G, Fitzharris P, Pearce N, Le Gros G, Beasley R (2000) Association of ß2-adrenergic receptor polymorphisms with severe asthma. Clin Exp Allergy, 30:1097-103
Hook S, Prout M, Camberis M, Konig M, Zimmer A, Van Heeke G, Le Gros G (2000) Th2-dependent airway eosinophilia is regulated by preproenkephalin. J Neuroimmunol, 107:59-65
Kirman J, Zakaria Z, McCoy K, Delahunt B, Le Gros G (2000) The role of eosinophils on the pathogenesis of Mycobacterium bovis BCG infection in interferon- receptor deficient mice. Infect Immun, 68:2976-8
Scanga CB, Le Gros G (2000) Development of an asthma vaccine: research into BCG. Drugs, 59:1217-21
Erb KJ, Hou S, Hyland L, Kirman J, Moll H, Le Gros G (1999) Constitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8+ T cells secreting interleukin 4 or interleukin 5. Immunol Lett, 68:383-90
Erb K, Kirman J, Delahunt B, Le Gros G (1999) Infection of mice with M. bovis BCG induces both Th1 and Th2 immune responses in the absence of Interferon- signalling. Eur Cytokine Netw, 10:147-54
Fraser H, Rincon M, McCoy K, Le Gros G (1999) CTLA4 ligation attenuates AP-1, NFAT and NF-kB activity in activated T cells. Eur J Immunol, 29:838-44
Harris N, Peach R, Ronchese F (1999) CTLA4-Ig inhibits optimal T Helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis. Eur J Immunol, 29:311-16
Harris N, Ronchese F (1999) The role of B7 co-stimulation in T cell immunity (Review). Immunol Cell Biol, 77:304-11
Hook S, Camberis M, Prout M, Konig M, Zimmer A, Van Heeke G, Le Gros G (1999) Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro. Immunol Cell Biol, 77:385-90
Hook S, Cheng P, Holloway J, Riley G, Sawyer G, Le Gros G, Beasley R (1999) Analysis of two IL-4 promoter polymorphisms in a cohort of atopic and asthmatic subjects. Exp Clin Immunogen, 16:33-5
Kirman J, McCoy K, Hook S, Prout M, Delahunt B, Orme I, Frank A, Le Gros G (1999) CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infect Immun, 67:3786-92
Lacy P, Mahmudi-Azer S, Bablitz B, Gilchrist M, Fitzharris P, Cheng D, Man SFP, Bokoch GM, Moqbel R (1999) Expression and translocation of Rac2 in eosinophils during superoxide generation. Immunology, 98:244-252
Adilah N, Fitzharris P, Crane J, Siebers R (1998) The effect of frequent vacuum cleaning on house dust mite allergen, Der p 1 in carpets: a pilot study. NZ Med J, 110:438-9
Crane J, Ellis I, Siebers R, Grimmet D, Lewis S, Fitzharris P (1998) A pilot study of heat exchange on mechanical ventilation and heat exchange on house dust mites and Der p 1 in New Zealand homes. Allergy, 53:755-62
Erb K, Holloway J, Sobeck A, Moll H, Le Gros G (1998) Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen induced airway eosinophilia. J Exp Med, 187:561-569
Erb K, Kirman J, Delahunt B, Chen W, Le Gros G (1998) IL-4, IL-5 and IL-10 are not required for the control of M. bovis BCG infection in mice. Immunol Cell Biol, 76:41
Erb K, Kirman J, Woodfield L, Wilson T, Collins DM, Watson JD, Le Gros G (1998) Identification of potential CD8+ T-cell epitopes of the 19 kDa and AHPC proteins from Mycobacterial tuberculosis - no evidence for CD8+ T-cell priming against the identified peptides after DNA-vaccination of mice. Vaccine, 16:692
Fitzharris P, Douglas R (1998) Allergic rhinitis. NZ Doctor, 19-28
Holloway J, Dunbar R, Riley G, Sawyer G, Fitzharris P, Pearce N, Le Gros G, Beasley R (1998) Association of b 2-adrenergic receptor polymorphisms with severe asthma. Amer J Resp Crit Care Med, in press
Kirman J, Le Gros G (1998) Which is the true regulator of Th2 cell development in allergic immune responses? Clin Exp Allergy, 28:908-10
Le Gros G, Erb K, Harris N, Holloway J, McCoy K, Ronchese F (1998) Immunoregulatory networks in asthma. Clin Exp Allergy, 28:92-6
Martin I, Wickens K, Patchett K, Kent R, Holbrook N, Fitzharris P, Siebers R, Smith S, Lewis S, Crane J, Town G (1998) Cat allergen levels in public places in New Zealand. NZ Med J, 111:356-8
McCoy K, Le Gros G (1998) The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol (in press)
Miles J, Sawyer G, Lewis S, Pearce N, Fitzharris P, Beasley R (1998) Classification of asthma severity: should the international guidelines be changed? Clin Exp Allergy, 28:1565-70
Riley G, Siebers R, Rains N, Crane J, Fitzharris P (1998) House dust mite allergen on skin and sheets. (Research letter) Lancet, 351:649-50
Sawyer G, Kemp T, Shaw R, Patchett K, Siebers R, Lewis S, Beasley R, Crane J, Fitzharris P (1998) Biological pollution in infant bedding in New Zealand: high allergen exposure during a vulnerable period. J Allergy Clin Immunol, 102:765-70
Siebers R, Fitzharris P, Crane J (1998) Home environment and asthma. (Letter). Thorax, 53:77-78
Siebers R, O'Grady G, Fitzharris P, Crane J (1998) House dust mite accumulation on sheepskins. NZ Med J, 111:408-9
Siebers R, Rains N, Fitzharris P, Crane J (1998) House dust mite allergen, Der p 1 in human hair. J Allergy Clin Immunol, 101:422-3
Wickins K, Fitzharris P, Crane J (1998) Increasing asthma prevalence in New Zealand: understanding the causes. NZ Public Health Rpt, 5:17-20
Harris N, Campbell C, Le Gros G, Ronchese F (1997) Blockade of CD28/B7 co-stimulation by mCTLA4-Hgamma1 inhibits antigen-induced lung eosinophilia but not Th2 cell development or recruitment in the lung. Eur J Immunol, 27:155-61
Harris N, Peach R, Naemura J, Linsley PS, Le Gros G, Ronchese F (1997) CD80 costimulation is essential for the induction of airway eosinophilia. J Exp Med, 185:177-82
Coyle AJ, Bertrand C, Tsuyuki S, Pircher H, Walti S, Le Gros G, Erard F (1996) IL-4 differentiates naïve CD8+ T cells to a "Th2-like" phenotype: a link between viral infections and bronchial asthma. Ann NY Acad Sci, 31:97-103
Erb KJ, Holloway JW, Le gros G (1996) Mast cells in the front line: Innate immunity. Curr. Biol. 6:941-2
Erb KJ, Le Gros G (1996) The role of Th2 type CD4+ T cells and Th2 type CD8+ T cells in asthma. Immunol Cell Biol, 74:206-8
Le Gros G, Schultze N, Walti S, Einsle K, Finkelman F, Kosco-Vilbois MH, Heusser C (1996) The development of IgE+ memory B cells following primary IgE immune responses. Eur J Immunol, 26:3042-7
Coyle AJ, Erard R, Bertrand C, Walti S, Pircher H, Le Gros G (1995) Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia. J Exp Med, 181:1229-33
Coyle AJ, Le Gros G, Bertrand C, Tsuyuki S, Heusser CH, Kopf M, Anderson GP (1995) Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cel Mol Biol, 13:54-9
Kopf M, Le Gros G, Coyle AJ, Kosco-Vilbois M, Brombacher F (1995) Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol Rev, 148:45-69
Seder RA, Le Gros G (1995) The functional role of CD8+ T helper type 2 cells. J Exp Med, 181:5-7
