Arthritis & Inflammation Group Publications

Martin WJ, Harper JL (2009) Innate inflammation and resolution in acute gout. Immunol Cell Biol, [Epub ahead of print 24 Nov 2009]

Martin WJ, Herst PM, Chia EW, Harper JL (2009) Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation. Free Radic Biol Med, 47:616-21 

Martin WJ, Walton M, Harper J (2009) Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum, 60:281-9

Chia EW, Grainger R, Harper JL (2008) Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine. Br J Pharmacol, 153:1288-95

Chia EW, Pearce A.N, Berridge MV, Larsen L, Perry NB, Sansom CE, Godfrey CA, Hanton LR, Lu G-L, Walton M, Denny W, Webb VL, Copp BR, Harper JL (2008) Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis. Bioorg Med Chem, 16:9432-42

Grainger R, Harrison A (2008) Infliximab in the treatment of Ankylosing Spondylitis. Biolog Targ Ther, (in press) 

Grainger R, Stuckey S, O'Sullivan R, Davis SR, Ebeling PR, Wluka AE (2008) What is the clinical and ethical importance of incidental abnormalities found by knee MRI? Arthritis Res Ther, 10:R18  

Grainger R, Taylor W (2008) Establishing outcome domains for evaluating treatment of acute and chronic gout. Curr Opin Rheumatol, 20:173-8 

Martin W-J, Walton M Harper JL (2008) Resident macrophages: initiating and driving inflammation in an MSU crystal-induced peritoneal model of acute gout. Arthritis Rheum, 60:281-9 supplementary data

Pearce AN, Chia EW, Berridge VB, Maas EW, Page MJ, Harper JL, Webb VL, Copp BR (2008)  Orthidines A - E, tubastrine, 3,4-dimethoxyphenethyl-b-guanidine and 1,14-sperminedihomovanillamide: potential anti-inflammatory alkaloids isolated from the New Zealand ascidian Aplidium orthium that act as inhibitors of neutrophil respiratory burst.  Tetrahedron 64:5748-55

Taylor WJ, Schumacher HR Jr, Baraf HS, Chapman P, Stamp L, Doherty M, McQueen FM, Dalbeth N, Schlesinger N, Furst DE, Vazquez-Mellado J, Becker MA, Kavanaugh A, Louthrenoo W, Bardin T, Khanna D, Simon LS, Yamanaka H, Choi HK, Zeng X, Strand V, Grainger R, Clegg D, Singh JA, Diaz-Torne C, Boers M, Gow P, Barskova V (2008) A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout. Ann Rheum Dis, 67:888-91; Epub 2007 Nov 29

Harper JL, Larsen D, Severn W, Singh G (2007) Synthetic molecules having immune activity. NZ Patent awarded 31st May 2007: Patented New Zealand No. 529603/533245

Pearce AN, Chia EW, Berridge MV, Clark GR, Harper JL, Larsen L, Maas EW, Page MJ, Perry NB, Webb VL, Copp BR (2007) Anti-inflammatory thiazine alkaloids isolated from the New Zealand ascidian Aplidium sp.: inhibitors of the neutrophil respiratory burst in a model of gouty arthritis. J Nat Prod, 70:936-40

Pearce AN, Chia EW, Berridge MV, Maas EW, Page MJ, Webb VL, Harper JL, Copp BR (2007) E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp. J Nat Prod 70:111-3

Sansom CE, Larsen L, Perry NB, Berridge MV, Chia EW, Harper JL, Webb VL (2007) An anti-proliferative bis-prenylated quinone from the New Zealand brown alga Perithalia capillaris. J Nat Prod, 70:2042-4 

Taylor WJ, Schumacher HR Jr, Singh JA, Grainger R, Dalbeth N (2007) Assessment of outcome in clinical trials of gout - a review of current measures. Rheumatology (Oxford), 46:1751-6

Ainge GD, Hudson J, Larsen DS, Painter GF, Gill GS, Harper JL (2006) Phosphatidylionsitol mannosides: synthesis and suppression of allergic airway disease. Bioorg Med Chem, 14:5632-42

Copp BR, Pearce AN, Denny WA, Berridge MV, Harper JL, Perry NB, Larsen L, Godfrey CA "Anti-inflammatory compounds" Patent PCT/NZ2005/000246, published as WO06/031134 on 23 March 2006

Harper JL, Larsen D, Severn W, Singh G "Synthetic molecules having immune activity", NZ 529603/533245, Patent Acceptance, December 2006

McNamara CE, Larsen L, Perry NB, Harper JL, Berridge MV, Chia EW, Kelly M, Webb VL (2005) Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli. J Nat Prod, 68:1431-3

Sayers I, Severn W, Scanga C, Hudson J, LeGros G, Harper JL (2004) Suppression of allergic airway disease using mycobacterial lipoglycans. J Allergy Clin Immunol. 114:302-9

Harper JL (2004) Can bacteria fight asthma? Editors choice- J Allerg Clinic Immunol, 114:212

Sayers I, LeGros G, Harper JL (2003) From hygiene hypothesis to novel allergic asthma therapies. Current Medicinal Chemistry 2:143-55

Beasley R, Shirtcliffe P, Holt S, Harper JL, Le Gros G (2002) Mycobacterium-based vaccines for the prevention of allergic disease - a progress report. Clinical and Experimental Allergy 32:1128-30